Mitotic cells get a stress test
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Mitotic cells get a stress test
Before they enter mitosis, cells duplicate their centrosomes so that they can form a proper, bipolar mitotic spindle. Cells with only one centrosome—or even no centrosomes at all—can still divide, but they tend to make errors in chromosome segregation. Healthy, nontransformed cells therefore apply the brakes when they lose their centrosomes, and arrest by up-regulating the tumor suppressor p53....
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2142if